Arachidonic acid
Diacylglycerol or phospholipid
Phospho-
lipase C
Lipooxygenase
(FLAP, Alox5)
HPETE (
hydroperoxy-
eicosatetraenoic acid)
Prostaglandin H
2
(PGH
2
)
Leukotriene A
4
Leukotriene D
4
Leukotriene E
4
H
2
O
LTB
4
Glutathione
Glutathione-
S-transferase
PGH
2
synthase
(cox-1 or -2 and
peroxidase)
PGD
2
PGD
synthase
PGE
2
PGF
2
PGE
synthase
Prostacyclin
(PGI
2
)
Thromboxane
(TXA
2
)
Thromboxane synthase
Prostacyclin synthase
Thromboxane
(TXA
2
)
6-keto-
PGF
1
α
platelets
endothelium
Phospho-
lipase A
2
Glutamic acid
Leukotriene C
4